Make sure your initial starting estimates are within about 7cm and about 20 degrees. There are loads of entries in the archives about how to do this. Best regards, -John On Tuesday 20 December 2005 16:00, Ji Hyun Ko wrote: > Hello, > > > > I just began to use the SPM2 for the PET analysis. > > It's a single subject water study. I have two conditions (two scans per > condition) and a structural MRI. > > > > I realigned all PET files (cond1_1.mnc; cond1_2.mnc; cond2_1.mnc; > cond2_2.mnc), so it produced a mean image and four resliced images. > > > > I think realignment was ok, but when I tried to coregister the PET files to > structural MRI, it produced blank images. > > > > Target: MRI > > Source: Mean PET > > Others: rcond1_1.img; rcond1_2.img; rcond2_1.img; rcond2_2.img > > > > I also tried: > > > > Target: MRI > > Source: rcond1_1.img > > Others: rcond1_2.img; rcond2_1.img; rcond2_2.img > > > > And, it didn't produce the correct preprocessed images. > > > > The initial format of the files was MINC. > > And, I checked all the minc files, and those files didn't seem to have any > problems. > > > > I am attaching the spm2 output file of the coregister. > > > > Thanks, > > > > Ji Hyun