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Hello, I just began to use the SPM2 for the PET analysis. It's a single subject water study. I have two conditions (two scans per condition) and a structural MRI. I realigned all PET files (cond1_1.mnc; cond1_2.mnc; cond2_1.mnc; cond2_2.mnc), so it produced a mean image and four resliced images. I think realignment was ok, but when I tried to coregister the PET files to structural MRI, it produced blank images. Target: MRI Source: Mean PET Others: rcond1_1.img; rcond1_2.img; rcond2_1.img; rcond2_2.img I also tried: Target: MRI Source: rcond1_1.img Others: rcond1_2.img; rcond2_1.img; rcond2_2.img And, it didn't produce the correct preprocessed images. The initial format of the files was MINC. And, I checked all the minc files, and those files didn't seem to have any problems. I am attaching the spm2 output file of the coregister. Thanks, Ji Hyun