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> Can someone please describe the settings to use in SPM2 for this > procedure? They are different from the defaults I remember from SPM99. Use "source weighting" rather than "object weighting". Best regards, -John > Neggers, S.F.W. (Bas) wrote: > >We used Matthew Brett's method, as published in NeuroImage: > > > >Brett M, Leff AP, Rorden C, Ashburner J. Spatial normalization of brain > > images with focal lesions using cost function masking. Neuroimage. 2001 > > Aug;14(2):486-500. > > > >http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt= > >Abstract&list_uids=11467921 > > > >It worked well for us, the papers are submitted at present. We didn't do > > VBM, but instead calculated lesion overlap ratios. I'm not sure with > > respect to VBM if this is what you want. > > > >Good luck, > > > >Bas > > > >-----Oorspronkelijk bericht----- > >Van: SPM (Statistical Parametric Mapping) > >[mailto:[log in to unmask]]Namens Yong Zhang > >Verzonden: woensdag 26 januari 2005 21:46 > >Aan: [log in to unmask] > >Onderwerp: [SPM] Spatial normalization with the existence of brain > >lesion > > > > > >Dear SPMers: > > > >Currently I am working on a VBM project comparing > >childhood brain tumor survivors with normal > >controls. The lesion region resulting from resection > >caused distortion during spatial normalization. > >To solve this problem, one methos is to use > >affine registration only and the other is to mask > >out the lesion region. I am wondering if there > >is any other solution for this problem. I > >searched the SPM achives, but very few > >documents were found for this issue. > >Where can I find more sources for this problem? > >Thanks a lot! > > > >Yong