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Thanks to all for the suggestions. I'll look into FSL and BrainVisa. Last time I checked (cursory examination) ImageJ did not have manual editing, but maybe I'm wrong about this...I'll check again. Warm Regards, Jeff ------------------------------------------ Jeffrey N. Browndyke, Ph.D. Assistant Professor - Dept. of Psychiatry Duke University Medical Center 2200 West Main St., Suite A-230 Durham, NC. 27705 (919)416-5383 voice (810)821-0424 fax [log in to unmask] ------------------------------------------