Dear SPMers: Currently I am working on a VBM project comparing childhood brain tumor survivors with normal controls. The lesion region resulting from resection caused distortion during spatial normalization. To solve this problem, one methos is to use affine registration only and the other is to mask out the lesion region. I am wondering if there is any other solution for this problem. I searched the SPM achives, but very few documents were found for this issue. Where can I find more sources for this problem? Thanks a lot! Yong