Hi everyone, My question has a few parts to it: 1. Is there any scenario under which in a single regression analysis the program should not allow me to even enter a 1 or -1 t contrast? (this is what is happening to me now; it only lets me enter an F contrast of 1 -1 or -1 1) 2. I am using the plot tool to look at a single regression of over 40 PETs from many subjects (one scan/subject) to assess the relationship of activation at a certain voxel with a continuous variable, using the aforementioned F contrast (1 -1 or -1 1--I get the same line either way). a. Can I infer from seeing a high r value (~0.7) with an inverse correlation relationship (r val is neg) that there indeed is more hypometabolism in the area with increasing value of my continuous variable? b. Even though I get the same line equation and r value with the different F contrasts (1 -1 and -1 1) I get slightly different areas of activation. It is not clear to me why exactly this happens. c. Final question, what exactly (in the plot tool) is the real difference between "predicted" and "adjusted"? What is the line being "adjusted" for exactly? Thank you so much for all your help! Best Regards, Aviva Olsavsky