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Dear SPMers, I have a study where there are two groups of Patients , Z(n=8) and P(n=7), Each subject had 2 scans (initial then 2 months later). Zpre Ppre Zpost Ppost With such small group sizes at this point in the study, is it still acceptable to present fixed effects model results or must I run Random Effects as well? I would like to test for the following contrasts: Zpre vs Zpost Ppre vs Ppost Zpre vs Ppre Zpost vs Ppost Please advise me as to what would be the most acceptable way to analyze this data set using spm99. thank you for your time, Maria