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Dear SPMers, I would like to perform a longitudinal VBM study on schizophrenic patients vs healthy controls. In a first step I did a baseline comparison between both groups (50 vs 50) using the optimized VBM procedure and compared the groups by a simple one- way ANOVA. Then the 44 follow-up scans (26 healthy, 18 schizophrenics) were realigned to the corresponding baseline scans and then normalized to the custom T1-template of my baseline VBM study, segmented and smoothed (8 FWHM). For the statistical analysis I used the PET model "multi-group: conditions and covariates". Are these steps correct or should I use different ways of preprocessing and statistical inference ? Thanks very much in advance for any suggestions... Nikos Koutsouleris Imaging Group Psychiatric Clinic, Ludwig-Maximilian-University, Munich