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Hi, We're looking for the best way to analyze a design like the following: - Two groups of subjects (ex: patients and controls) - two levels of treatment (ex: drug and placebo) Each subject has 2 scans from separate days. One for the drug condition and one for placebo. What's the easiest and/or best way to look at the group RFX? One idea we had was to just model both scans in one large design matrix (as in this post http://www.jiscmail.ac.uk/cgi-bin/wa.exe?A2=ind0502&L=SPM&D=0&I=-3&X=334B9904DDB400BF3B&Y=&P=15311) But we weren't sure if that was the best way. Since SPM2 doesn't offer a 2-way ANOVA, what's the best option to run something like that? Is there a script someone has to make SPM2 do a 2-way? Or could I fake it with a one-way ANOVA with 4 conditions (ex: patient_drug, patient_placebo, control_drug, control_placebo)? Thanks -Mike