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Hello, I am working with data from an AD population and have used Christian Gaser's create template and optimized VBM procedures in order to generate the template and priors and also the normalization parameters (from VBM) to apply to perfusion MRI images. The perfusion images are 7 slice and have been masked for gray matter and partial volume corrected. I used the default [2 2 2] dimensions when I applied the normalization parameters to the perfusion image. I also wrote the normalized image with [1 1 1], since this is how the parameters were generated in the first place in VBM. The normalized perfusion image looks strange to me (with both [1 1 1] and [2 2 2]) and I am unsure what the best procedure for normalization might be in my case. I have attached the normalized perfusion image [2 2 2]. Thanks! Audrey BTW: the dimensions of the perfusion image before normalization were 128 x 128 x 7 with 2.34 x 2.34 x 10 voxels. The warped T1 image from VBM was 157 x 189 x 156. My T1 template and priors looked very good. Audrey Duarte, Ph.D. Postdoctoral Researcher San Francisco VAMC 4150 Clement St, Mail stop:116R San Francisco, Ca 94121 415-221-4810 x 3852