 |
 |
Dear All Does anyone have any experience of transient increases in fT4 and fT3 post administration of chloral for sedation? We have at least 3 children (ages 5 to 17) whose results have had fT4 30-45 pmol/L (upper limit of normal 23 pmol/L), fT3 >8 pmol/L (upper limit 6.8 pmol/L with a normal TSH, when chloral has been used for sedation prior to blood sampling, Two of the children have subsequently had samples taken when sedated by other methods (melatonin or pre ENT procedure) and have had euthyroid results. They have no thyroid history and no medications known to affect TFTs. Is it an interference in the assay, displacement from binding proteins or a physiological response? Would the TSH respond later (as in overdoses) and suppress? Is there a risk to patients, or perhaps only those with impaired cardiac function? What about patients on therapeutic chloral (the doses here are about a third to a quarter of those for sedation)? Thanks in advance for your help Caroline Jagger This message and any files transmitted with it are confidential and intended solely for the individual(s) addressed. If you have received this e-mail in error, disclosing, copying, distributing or retaining this message or any part of it is strictly prohibited; please notify the sender immediately and delete it from your system. Any views or opinions presented are solely those of the author and do not necessarily represent those of Lancashire Teaching Hospitals NHS Foundation Trust. The Trust accepts no liability for any damage caused by any virus transmitted with this e-mail, so although virus checked before transmission, the recipient should also check for the presence of viruses. The information contained in this email may be subject to public disclosure under the NHS Code of Openness or the Freedom of Information Act 2000. Unless the information is legally exempt from disclosure, the confidentiality of this email and any subsequent reply cannot be guaranteed. Web:- http://www.lancsteachinghospitals.nhs.uk ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/