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Mick, Yes, you are right on target with that observation. When looking for Therapy articles on PubMed, you are selecting the "RCT filter". You can turn your Etiology and Prognosis questions to look at a therapy question. Your Etiology question would be something like; "Is the use of therapy X associated with a particular outcome Y (positive or negative)?" This would get you to case control studies. Similarly, your Prognosis question could look like: "What happens to patients who get therapy X compared to therapy Y for outcome Z?" This would get you to cohort studies A bit bulky, but should work for you. Dan **************************************************************************** Dan Mayer, MD Professor of Emergency Medicine Albany Medical College 47 New Scotland Ave. Albany, NY, 12208 Ph; 518-262-6180 FAX; 518-262-5029 E-mail; [log in to unmask] **************************************************************************** >>> Mick Arber <[log in to unmask]> 10/28/2004 1:25:29 PM >>> Hi Paul, Thanks very much for your reply. I have taken a look at these before, but I'm not sure how well they would work to retrieve therapy papers, as oppose to etiology or prognosis. What do you think? There is a therapy filter on PubMed, but it doesn't seem designed to retrieve observational studies (or all cohort / case-control / case-series). Thanks for your help, best wishes, Mick Mick Arber, Information Specialist BMJ Knowledge BMJ Publishing Group, BMA House Tavistock Square, London. WC1H 9JR http://www.clinicalevidence.com http://www.besttreatments.co.uk Tel: 020 7383 6385 Fax: 020 7383 6242 Paul Glasziou <[log in to unmask]> 28/10/2004 18:00 To Mick Arber <[log in to unmask]> cc [log in to unmask] Subject Re: Study design filters for therapy observational studies At 28/10/2004, Mick Arber wrote: Apologies for cross-posting. Does anyone know of any validated search filters used to retrieve observational studies (cohort, case-control, case-series) on therapy? Thanks for your help, Mick You could consider the PubMed: Clinical Queries filters for (a) prognosis (cohort studies) and etiology (case-control studies). They have been updated this year and are much improved. http://www.ncbi.nlm.nih.gov/entrez/query/static/clinical.html Paul Glasziou Department of Primary Health Care & Director, Centre for Evidence-Based Practice, Oxford ph: 44-1865-227055 www.cebm.net ForwardSourceID:NT0000BD9E