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Dear Tracey, Greetings from Southend on the east coast of England. According to this policy from the University hospital Birmingham priming with saline is not required (page 15 last two lines) http://www.uhb.nhs.uk/about/policies/policies/all_policies/blood_trans.pdf Here is a blood transfusion nursing policy from Ireland. According to this policy, (see page 19) the giving sets should be primed with saline only when administering platelets. http://www.mwhb.ie/documentation/pandp/pandp/acute/stjosephs/jos1_3bloodtransfusionpolicy.pdf You might also find this transfusion medicine handbook from New Zealand of interest. http://www.nzblood.co.nz/downloads/hbk_handbook.pdf (Beware it is 97 pages long!) Hope the above is of some interest ?help. Regards & very best wishes, Badri Dr.P.Badrinath MD, BS, M.Phil, MPH, PhD (Cantab), MFPHMI Specialist Registrar in Public Health & Recognised Clinical Teacher, Southend-on-Sea PCT & University of Cambridge, UK. _________________________________________________________________ Sign-up for a FREE BT Broadband connection today! http://www.msn.co.uk/specials/btbroadband