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Hi, a question: how would you design and analyse a functional imaging experiment where you are interested in not rejecting the null hypothesis. that is, where you don't want to see a difference between two conditions. is there a great example in literature? asking some knowledgeable people, there was the suggestion to lower the thresholds. but you always see something in SPM when lowering the thresholds.... is there a more elegant way of doing it? I would be happy with any comment. thanks in advance! Johannes Dr. med. Johannes Chr. Gerber FA Diagnostische Radiologie Abteilung Neuroradiologie Institut und Poliklinik für Radiologische Diagnostik Universitätsklinikum Dresden D-01304 Dresden Tel.: 0351-458 5227 / -2660 Fax.: 0351-458 4370