Dear all, I would like to present a question concerning proceeding from ANOVA to pairwise t-testing. We have performed analysis analogous to the ANOVA 1 factor 4-levels example in FEAT manual (in our case 3 levels) and in the resulting F-statistic certain areas survive the significance threshold used. In an analysis analogous to the pairwise t-test example in FEAT manual we see that in one of the comparisons between two levels there are voxels that survive the thresholding and overlap those seen in ANOVA. In addiotion there are activated voxels outside ANOVA areas. Should we use the ANOVA thresholded activation as mask for pairwise comparisons using t-test (i.e. should we discard voxels from further analysis that showed no effect in ANOVA), and if so, how to correctly set up that? Yours, Antti Korvenoja -- Antti Korvenoja Biomedicum Helsinki, Radiology P.O. Box 700, 00029 HUS Finland tel: +358-9-47171786 : mobile: +358-40-7498469