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Serge, > I am not really sure how to get the inferred basis set IRF, in each voxel. I > think I would have to calculate a 4D image, using PE1*BRF1(t) + PE2*BRF2(t) > + PE3*BRF3(t) (where PE=image of parameter estimates, BRF=basis response > function). Does this make sense? That sounds right to me. Cheers, Mark. Mark Woolrich. Oxford University Centre for Functional MRI of the Brain (FMRIB), John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK. Tel: (+44)1865-222782 Homepage: http://www.fmrib.ox.ac.uk/~woolrich