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Hi Lucina, Assuming the 7EVs do not include rest, yes those contrasts are correct. Each of them will results in a t-test comparing the mean activity in the various conditions to rest. For instance, in your rest - 7 EVs, you'll find regions where the mean activation across all 7 EVs decreases relative to rest. Obviously any one condition may show a different pattern in that same region though Joe -------------------- Joseph T. Devlin, Ph. D. FMRIB Centre, Dept. of Clinical Neurology University of Oxford John Radcliffe Hospital Headley Way, Headington Oxford OX3 9DU Phone: 01865 222 738 Email: [log in to unmask]