Please note that the email send yesterday contained the incorrect course fees for academic institutions and registered charities. The correct course fee is 595 pounds. Here is the email again - apologies for the error and the resulting second email. MIXED MODELS ANALYSIS OF MEDICAL DATA USING SAS 29 September - 1 October 2004 This course will cover the statistical background to the mixed model and will emphasise its practical application in medical data with particular reference to clinical trials. All analyses will be illustrated using SAS and lectures will be combined with practical sessions in order to reinforce concepts. Topics covered include: DAY 1 o General concepts and underlying statistical theory o Use and interpretation of PROC MIXED o Multi-centre trials and meta-analysis o Consideration of issues such as biased standard errors, significance testing and negative variance components. DAY 2 o Repeated measures trials o Random coefficients models o Crossover trials o More complex trial designs o Introduction to Bayesian methods. DAY 3 o Generalised linear mixed models o Mixed models for ordinal data o Use of SAS for fitting mixed models to non-normal data. THE SPEAKERS Robin Prescott Robin is Director of the Medical Statistics Unit of The University of Edinburgh and is Professor of Health Technology Assessment. He has been working in the medical field for over thirty years and has a particular interest in cross-over trials. He has wide experience of multi-centre trials and of working with the pharmaceutical industry. Helen Brown Helen is a Principal Statistician within NHSScotland. She has twenty years of practical experience as a medical statistician with experience in both academic and commercial environments. She has a research interest in the application of mixed models in the medical field. The speakers are the authors of Applied Mixed Models in Medicine, in the John Wiley Statistics in Practice series . WHO SHOULD ATTEND This course is directed at medical statisticians who wish to understand the statistical background to mixed models and to carry out analyses using SAS. WHY ATTEND Conventionally, clinical data is analysed using fixed effects models. However, benefits can often be gained by using a mixed model. For example: in repeated measures trials full allowance can be made for the correlation occurring between the repeated observations even if data are missing; in multicentre trials or meta analyses treatment standard errors are more appropriately based on between centre/trial variation (fixed effects standard errors are based on within centre/trial variation); in crossover trials more accurate treatment means are often achieved by combining within and between patient estimates. Previously the use of these models has been limited by heavy computational requirements and a lack of generally available software, but this is now much less of a restriction with the introduction of suitable procedures into well known packages such as SAS. As with any statistical technique a firm understanding of the theoretical background is essential to allow its effective application and to obtain a clear interpretation of results. COURSE FEES Standard rate £795 Academic institutions and registered charities £595. Fees include daily morning coffee, lunch, afternoon tea, a course dinner and a delegate's pack including full course notes. REGISTRATION AND FURTHER INFORMATION To reserve your place(s), please complete the registration form on the inside cover and fax or post it to: Office of Lifelong Learning - CPD Unit 11 Buccleuch Place Edinburgh EH8 9LW Tel: 0131 651 1819 Fax: 0131 651 1746 Email: [log in to unmask] Alternatively you can book online at: www.lifelong.ed.ac.uk/cpd/courses TERMS AND CONDITIONS Payment should accompany your registration form. If invoiced, fees must be paid in full by the day before the course is due to commence. Failure to pay may result in attendance being refused. For cancellations received in writing at least five working days before the course commences, a 20% administrative charge will be made. After this date, fees will not normally be refunded but places are fully transferable. The University of Edinburgh reserves the right to cancel or postpone the course, in which case fees will be refunded in full. In the event of cancellation, The University of Edinburgh will not be held liable for registrants' travel or accommodation costs. All payments should be in sterling. Please note that participants are responsible for payment of any bank charges incurred. VENUE The course will take place in the Holiday Inn, Edinburgh-North, one mile from the city centre and easily accessible from the main railway station and airport. ACCOMMODATION Course participants have the opportunity to stay at the Holiday Inn, Edinburgh-North at the reduced rate of £80 per night. All bedrooms in the hotel have modem points. For further information please contact Reservations on 0131 332 2442 quoting The University of Edinburgh. Alternatively please contact our accommodation agency, Murray Accommodation. Telephone: 08707 509808 Email: [log in to unmask] or visit www.murray-accommodation.co.uk