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A new version of the Clinical Trial Simulator (CTS) is available for download. David Sackett also kindly contributed a Power Point presentation with examples on how to use the simulator. Plase go to www.randomization.org for more information. What is the Clinical Trial Simulator (CTS)? The Clinical Trial Simulator is a free software package that can simulate Randomized Controlled Clinical Trials (RCTs). With the CTS a user can explore aspects of the design, conduction and analyses of RCTs. Typically, the user conceives a trial, including patients subgroups, sample size, outcome rates, effect size, lost to follow-up, patients compliance, etc. Then the program generates 1000s of such trials. A summary of the results is presented, including relative risks, relative risk reductions, confidence intervals, p-values, etc. A number of graphics is also available. What can be used for? To learn how to design, analyze and report RCTs. The program tries to comply with the recommendations of the CONSORT statement when reporting the results of the trials. To answer questions like: "What if I lose 30% of the patients?", or "What if 10% of the patients do not take their study pills? What is the likely impact of these problems on the results of the study? In the current version the user can define the proportion of patients that are lost-to-follow-up, and the proportion not complying with assigned intervention, in one or more populations subgroups. To explore the impact of sample size on study results. Can be also used as a sample size calculator, taking into account the impact of lost to follow-up and protocol violations. To explore the impact on sample size of changing inclusion/exclusion criteria by changing the risk profile of included patients. To use and teach "physiological statistics".