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Dear Gorge, You should use a Cox model with a frailty term modeling the intrasubject correlation within the twin-pairs. Literature: Hougaard. Analysis of Multivariate Survival Data. (2000). Springer, New York. Therneau & Grambsch: Modeling Survival Data. Extending the Cox Model (2000). Springer. New York. ---------------------------------------------------------------------------- --------------------------- Dr Bernd Genser MSc, PhD General Manager BGStats Consulting Statistical Consulting - Data Analysis - Medical Research Support email: [log in to unmask] Office Austria: + 43 (664) 516-4918 or (3135) 49-815 Office Brazil: + 55 (71) 8822-0414 or 264-0414 HYPERLINK "http://www.bgstats.com"www.bgstats.com ---------------------------------------------------------------------------- ---------------------------- --- Outgoing mail is certified Virus Free. Checked by AVG anti-virus system (http://www.grisoft.com). Version: 6.0.681 / Virus Database: 443 - Release Date: 10.05.2004