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Dear all, I'm looking for software for the following data situation: - Multivariate survival data (Recurrent diarrhea infections) - (Continuous) time dependent covariates (different time scales like age, time since beginning of the study, etc. ) - Random effect (frailty) to model the heterogeneity among individuals or marginal approach (WLW, PWP model) to adjust the variance estimators I would like to fit an extended Cox model using a frailty term or an robust variance estimation to estimate risk factors for diarrhea infections. What I know: In S-Plus it is possible but not with continuous covariates. In STATA incl. of frailty it is possible but only for parametric Survival analysis In SAS I found some macros for an robust WLW approach but they do not work with time dependent covariates ---------------------------------------------------------------------------- --------------------------- Dr Bernd Genser Department of Public Health Federal University of Bahia Salvador, Brazil email: [log in to unmask] <http://www.bgstats.com> www.bgstats.com ---------------------------------------------------------------------------- ----------------------------