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Hi Everybody, I'm writing up a SAP for a prospective observational study involving health resource outcomes of two competing drugs. My client wants me to put in far too many primary pieces of analysis but that's just how it is. I have two questions - any help on either much appreciated - I'll summarise and post back the responses. I've been asked to conduct patient matched analysis (i.e. matching 1 patient on drug X with 1 on Y) - I've been given the variables to match on. My background is econometrics so I don't know much about this topic. Is there a package out there anyone can recommend that can do the matching in either R or Stata or Ox - I've not a clue as to what to do if 2+ people from drug X perfectly match 1 person on drug Y and the fact my sample won't be equal sizes - likely to be 2 to 1. The other analysis is using standard technques to model the occurances of certain outcomes (eg hospital visits) in a specified period. I'm doing the usual time to event analysis, but the client also wants me to model either the number of occurances in the period (Posisson/Neg Binomial model) or just whether the event occurs (Logistic). My question is there a guide as what percent of patients having a count greater than 1 is a cut off that dictates whether to model the counts or just whether the event occurred? I want to put this cutoff in my SAP so I can use it dictate my modelling - no idea if this is legitimate? Any help much appreciated. Steve Stephen Kay Head of Statistics Adelphi Group Products www.adelphigroup.com DISCLAIMER: The information in this message is confidential and may be legally privileged. It is intended solely for the addressee. Access to this message by anyone else is unauthorised. If you are not the intended recipient, any disclosure, copying, or distribution of the message, or any action or omission taken by you in reliance on it, is prohibited and may be unlawful. Please immediately contact the sender if you have received this message in error. Thank you.