I think it was because the patient was taking zinc
supplements to aid wound healing an dthe medic thought
this would affect her HbA1c
This is an abstract from a paper
"The urinary excretion of zinc in individuals with
insulin-dependent diabetes mellitus (IDDM) is
approximately doubled. In the absence of a
compensatory mechanism, this hyperzincuria should
induce a deficient or marginal Zn status. We examined
parameters of Zn status in plasma and in blood cells
with respect to urinary Zn losses and Zn
supplementation. We measured Zn levels in the urine,
plasma, and erythrocytes of 14 IDDM subjects and 15
nondiabetics who kept dietary records for 3
consecutive days. Subsequently, six IDDM subjects and
seven nondiabetics were supplemented with 50 mg Zn
daily for 28 days. We measured the above parameters,
as well as mononuclear leukocyte Zn (MNL-Zn) and the
plasma subfraction of albumin-bound Zn (alb-Zn). The
total plasma Zn-binding capacity was also assessed.
Plasma copper and erythrocyte Cu were monitored as
indicators of potential Zn toxicity. Individuals with
IDDM displayed the expected hyperzincuria, but had
normal blood Zn parameters. Zincuria increased by a
similar amount in both groups during supplementation,
as did the MNL-Zn content. However, erythrocyte Zn
(e-Zn) was refractory, so a trend toward lower e-Zn
among IDDM subjects persisted during Zn
supplementation. Hemoglobin A1c (HbA1c) increased
markedly in the Zn-supplemented IDDM group. Despite
their chronic hyperzincuria, individuals with IDDM
appear not to be Zn-deficient. Large-dose Zn
supplementation increases MNL-Zn and induces an
undesirable elevation of HbA1c in all individuals.
This is especially disconcerting for those with IDDM,
and may reflect an exacerbation of a chronic "Zn
diabetes." These data suggest a potential for toxicity
from large-dose Zn supplementation"
David Brown
--- Martin Holland <[log in to unmask]>
wrote:
> That must have been a HUGE bite. Sure it was not a
> shark?
>
> :-)
>
> Martin.
>
>
> -----Original Message-----
> From: Williams David G (RLN) City Hospitals
> Sunderland - Clinical
> Scientist [mailto:[log in to unmask]]
> Sent: 26 October 2004 10:26
> To: [log in to unmask]
> Subject: It makes you wonder
>
>
> Request for HbA1c (which was normal) - clinical
> details "Dog Bite left arm"
>
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=====
David G Brown
Valencia
Espaņa
Tel 00 34 96 328 7207
mov. 00 34 676064278
e-mail [log in to unmask]
http://www.proz.com/pro/56276
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