I have a question relating to segmentation with FAST.
I have been trying to use prior probabilities for initialization and for final segmentation in order to obtain more accurate segmentation of the basal ganglia, particularly the thalamus. I assume that in order to use prior probability masks the program tries to register the volume to be segmented to a template.
Can the segmentation go very wrong if the volume to be segmented is tilted by a large angle in respect to standard space? I think FAST works better on deskulled volumes, but the skull can provide useful info for accurate registration to a template, so if I want to use priors, should I deskull the volume before or after segmentation?
What happens if the brain I want to segment is much smaller or deformed in unusual ways as compared to the template? Can this result in inaccurate segmentation, due to poor registration with the template?
Thanks for your help....
Stefano Marenco, MD
Senior Staff Fellow
Clinical Brain Disorders Branch
NIMH
10 Center Drive, room 4S235
Bethesda, MD 20817
tel. (301) 435-8964
fax. (301) 480-7795