Dear FSL-Experts, I´m currently working with some unfortunate data which was acquired with non-optimal acquistion parameters. The main problem is that the group, who performed the experiment used a PRESTO sequence in which the TR was determined individually for each subject. So now i have scans with differnet TRs (differences ranging from something like 0.2 to around 0,6 secs) from each subject. From a discussion on the SPM mailing list some time ago, i remember that it was not possible to analyze these scans because of unequal covariance or somenthing like that. As i understand it, FSL mixed effect approach allows one to analyze data from unbalanced designs, would it also be possible and valid to analyze scans with different TRs? all the best, Martin Martin Kronbichler Institute of Psychology University of Salzuburg Hellbrunnerstr. 34 5020 Salzburg Austria tel.: 0662/8044-5162 fax.: 0662/8044-5126 e-mail: [log in to unmask]