In my questions experiment, I have seven different explanatory variables (categories of questions). For each of the twenty eight questions asked during a session, there are three volumes collected (question being asked, answering, and rest (TR=4)). I set up the explanatory variables in FSL using the rest volumes. Now, I am trying to make sure I understand what I will be getting using different types of contrasts. In particular, I am trying to understand the implications of demeaning in FSL. One contrast I could look at is: A C L M R T U A 1 0 0 0 0 0 0 From my understanding, this gives me the mean activation under the A condition, having already subtracted out the mean level of activation during the entire experiment (ACLMRTU x qar) Another contrast would be: A C L M R T U A 6 -1 -1 -1 -1 -1 -1 My best guess of this contrast is that it is going to show me the activations for A that are distinct from activations that are happening in CLMRTU. So, I think that the first contrast would show activations like the finger press or the auditory activations. And, I guess I would expect that all seven conditions would look pretty similar since I would expect the obvious motor or sensory activations to obscure the more subtle cognitive differences. And, I would assume that the second contrast would take out the common motor and sensory activations and highlight the cognitive differences particular to condition A. Is that correct? Further more, how would I use the F test in this case. I am familiar with the meaning of F tests when I use them to evaluate whether the differences between to subject populations are statistically significant. But, I am not clear on the meaning of the maps generated by using an F test in FSL. Thanks in advance, Darren