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Reply posted on behalf of Peter George, Clinical Director, Canterbury Health Labs, Christchurch, New Zealand - [log in to unmask] Definitely do a lipoprotein electrophoresis to see if there is alpha lipoprotein or not. I assume that you can not do lipoprotein ultracentrifugation what about apoAI levels? Paraprotein seems less likely as HDL was OK when measured in Jan 2003. I have seen this in patients on Bezafibrate - it is a rare paradoxical effect - and in patients receiving chelation therapy for cardiac disease. In the second case I think it is due to very high levels of co-administered absorbate +/- EDTA in the chelation infusion. Hope this helps, Peter "If you have more than enough then you have someone elses" Trevor Walmsley, Canterbury Health Labs, Christchurch, New Zealand. Phone: (0064 3) 364 0326 Fax:Phone: (0064 3) 364 0320 eMail: [log in to unmask] Internet: http://www.cdhb.govt.nz/chlabs/staff/trevorw.htm ********************************************************************** ** This email and attachments have been scanned for content and viruses and is believed to be clean ** This email or attachments may contain confidential or legally privileged information intended for the sole use of the addressee(s). Any use, redistribution, disclosure, or reproduction of this message, except as intended, is prohibited. If you received this email in error, please notify the sender and remove all copies of the message, including any attachments. Any views or opinions expressed in this email (unless otherwise stated) may not represent those of Canterbury District Health Board ********************************************************************** ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/