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I am not aware of more recent data since work I did with Juanita Crook a few years ago in a cohort of 102 men treated with external beam radiation. PSA and F/T PSA ratio were measured during routine follow-up visits, some of which included repeat biopsies. (JM Crook and PS Bunting, Percent free PSA after radiotherapy for prostate cancer. Urology 1998;52:100-105). Median follow-up was only 40 months, and there was some benefit to the ratio in predicting positive biopsy, especially when post-radiation total PSA was between 0.6 and 2.0 ug/L. More follow-up was deemed necessary, but she moved to the University Health Network in Toronto, and and I moved to The Ottawa Hospital Ottawa, and we have lost touch in recent years ... Peter S Bunting, PhD DCC FCACB Clinical Biochemist Pathology and Laboratory Medicine The Ottawa Hospital 1053 Carling Avenue Ottawa ON K1Y 4E9 Phone: 613-798-5555 x 16106 Fax (shared): 613-761-5401 > -----Original Message----- > From: Gary Mascall [SMTP:[log in to unmask]] > Sent: Tuesday, April 22, 2003 10:55 AM > To: [log in to unmask] > Subject: Free PSA Ratio post Bracy/Radio therapy > > Had an interesting discussion with a Urologist who asked if I knew whether > the Free PSA Ratio switched towards normal after successful non surgical > radiotherapy treatment in patients with low total PSA levels but with Free > PSA Ratios of less that 10%. He runs a Urology assessment clinic, has done > for 10 years, and we offer same day service for lab tests, but he is > seeing > more and younger patients with normal Total PSA levels (<3), with low > ratios and positive biopsies. He just wondered if there was any way of > using the ratio to help him decide whether treatment was working, > especially as the levels of change in Total PSA at these levels is most > likely going to be within individual and laboratory error, so saying it > has > fallen from 1.2 to 1.1 total PSA is really no use(strange to see a surgeon > quite so clued up on the statistics of change in laboratory results). > > I haven't been able to find anything on Medline or other literature > searches, so I wonder if there is any knowledge out there about this, and > if so, what use or not it is. > > Thanks, > > Gary Mascall > Kidderminster Hospital > Worcestershire > > ------ACB discussion List Information-------- > This is an open discussion list for the academic and clinical > community working in clinical biochemistry. > Please note, archived messages are public and can be viewed > via the internet. Views expressed are those of the individual and > they are responsible for all message content. > > ACB Web Site > http://www.acb.org.uk > List Archives > http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html > List Instructions (How to leave etc.) > http://www.jiscmail.ac.uk/ ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/