Date sent: Mon, 28 Jul 2003 16:45:42 +0100 (BST)
From: Mohammad Al-Jubouri <[log in to unmask]>
Subject: Re: Creatine Phosphate and High Levels of CK
To: Dr Pat Twomey <[log in to unmask]>,
[log in to unmask]
Mohammad,
I do not have a reference to hand but I have seen a patient at our
lipid clinic go from a CK of c3,000 to c77 in <4 days upon stopping
a statin.
The kinetics (especially the release) is not necessarily the same
for drug induced myositis as a M.I. but I do not have a reference to
hand for this either.
Pat
> Pat,
>
> A raised skeletal muscle CK of 10 X URL (i.e 2000
> IU/L) for whatever cause can't return back to normal
> within 48 h due to its slow clearance kinetic. Can you
> provide us with a reference please. Also statins seem
> to magnify the increase in CK levels that may follow
> exercise.
>
> Mohammad
> --- Dr Pat Twomey <[log in to unmask]> wrote:
> > Date sent: Thu, 24 Jul 2003 16:39:53
> > +0100
> > Send reply to: Mohammad Al-Jubouri
> > <[log in to unmask]>
> > From: Mohammad Al-Jubouri
> > <[log in to unmask]>
> > Subject: Re: Creatine Phosphate and
> > High Levels of CK
> > To:
> > [log in to unmask]
> >
> > Mohammad,
> >
> > In statin (and Fibrate) induced myositis, i.e. CK >
> > 10 time URL, the
> > CK frequently goes back to the pre-treatment level
> > within 48 hours.
> > Not sure about other drugs.
> >
> > Did the patient continue to exercise or not?
> >
> > Pat
> >
> > > Raised CK is more likely to be due physical
> > activity
> > > because of rapid decline over three days. Drug
> > induced
> > > rise in CK is unlikely to settle over this short
> > > period.
> > >
> > > Mohammad
> > > --- LLOYD Geoff
> > > <[log in to unmask]> wrote: >
> > A
> > > 26 year old who has been on Olazipine (atypical
> > > > neuroleptics) for
> > > > schizophrenia was referred to us because of high
> > > > CK:890. In addition to
> > > > Olazipine, the patient has also been taking
> > creatine
> > > > phosphate for body
> > > > building purposes. The creatine phosphate was
> > not
> > > > prescribed by any
> > > > practitioner. In order to find the possible
> > cause of
> > > > the raised CK, both
> > > > medications were stopped, and 3 days later, the
> > CK
> > > > levels were back to
> > > > normal (117)! The pertinent question is:
> > > > Does anyone have any experience with high CK
> > > > following prolonged
> > > > administration of creatine phosphate or, could
> > this
> > > > be due to olazipine
> > > >
> > > > Many thanks
> > > >
> > > > Dr Rasaq Olufadi
> > > >
> > > > Please reply to:
> > > > [log in to unmask]
> > > >
> > > >
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> > > =====
> > > Dr. M A Al-Jubouri
> > > Consultant Chemical Pathologist
> > >
> > >
> >
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> =====
> Dr. M A Al-Jubouri
> Consultant Chemical Pathologist
>
> ________________________________________________________________________
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