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Dear Rasaq, Raised CPK and neuroleptic malignant syndrome have been well described in patients taking neuroleptic drugs. We recently had a patient taking Olanzipine with a CPK of 58,000 u/L but without symptoms of NMS (however with severe hyponatraemia) , and found two case reports of raised CPKs associated with neuroleptic drugs without symptoms of NMS. Peter Gosling Clinical Biochemistry Selly Oak Hospital University Hospital Birmingham NHS Trust Birmingham B29 6JD Tel 0121 627 1627 Ex 52272 -----Original Message----- From: LLOYD Geoff [mailto:[log in to unmask]] Sent: 24 July 2003 11:48 To: [log in to unmask] Subject: Creatine Phosphate and High Levels of CK A 26 year old who has been on Olazipine (atypical neuroleptics) for schizophrenia was referred to us because of high CK:890. In addition to Olazipine, the patient has also been taking creatine phosphate for body building purposes. The creatine phosphate was not prescribed by any practitioner. In order to find the possible cause of the raised CK, both medications were stopped, and 3 days later, the CK levels were back to normal (117)! The pertinent question is: Does anyone have any experience with high CK following prolonged administration of creatine phosphate or, could this be due to olazipine Many thanks Dr Rasaq Olufadi Please reply to: [log in to unmask] <mailto:[log in to unmask]> ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ DISCLAIMER: This e-mail contains proprietary information some or all of which may be confidential or legally privileged. It is for the exclusive use of the intended recipient(s) only. If an addressing or transmission error has misdirected this e-mail and you are not the intended recipient(s), please notify the author by replying to this e-mail. If you are not the intended recipient you must not use, disclose, distribute, copy, print, or rely on this e-mail, as this may be unlawful. ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/