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This was our primary screen for a number of years before our volume reached the point where automation was practical. It was an excellent product from a very cooperative company. They sent me hundreds of pages of detailed cross-reactivity tables and were willing (at the time) to work up problem specimens at no charge. A couple of observations:
1. While the positive stripes are very easy to read, occasionally a VERY faint band would form that could not be confirmed. We adopted a rule that you didn't call it positive unless you could see both edges of the purple stripe clearly defined, and this served us very well.
2. The Tricyclic Antidepressant test cross-reacted with therapeutic concentrations of cyclobenzaprine.
3. The Benzodiazepine test cross-reacted with a metabolite of the antidepressant Zoloft.
4. We had several instances of false positives on the Amphetamine test on patients who were undergoing extreme stress (a psychotic episode and a difficult childbirth) that were repeatable both here and by Biosites Tech Service lab, but could not be identified as any of the usual amphetamine-like substances.
5. The incubation time cannot be decreased without losing sensitivity, and likewise you cannot run cold specimens without losing sensitivity. Follow the manufacturer's procedure and it is an excellent (if somewhat expensive) product, however.
These observations are several years old, and I can't say what kind of support the company gives these days.
I wish the manufacturer of the FPIA assays I now use could be so forthcoming with cross-reactivity data.
Gary Sandberg MT(ASCP) SC
chemistry supervisor
St.Joseph Hospital
Bellingham, WA USA
-----Original Message-----
From: PETER HOWELL [mailto:[log in to unmask]]
Sent: Wednesday, July 02, 2003 12:43 AM
To: [log in to unmask]
Subject: Triage Tox Drug Screen
Good Morning to All
Has anyone any experience of the Triage Tox Drug Screen System, either in the lab or as a POCT system ?
Peter
Peter Howell
Wrexham Maelor Hospital
Wrexham
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