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This was our primary screen for a number of years before our volume reached the point where automation was practical. It was an excellent product from a very cooperative company. They sent me hundreds of pages of detailed cross-reactivity tables and were willing (at the time) to work up problem specimens at no charge. A couple of observations: 1. While the positive stripes are very easy to read, occasionally a VERY faint band would form that could not be confirmed. We adopted a rule that you didn't call it positive unless you could see both edges of the purple stripe clearly defined, and this served us very well. 2. The Tricyclic Antidepressant test cross-reacted with therapeutic concentrations of cyclobenzaprine. 3. The Benzodiazepine test cross-reacted with a metabolite of the antidepressant Zoloft. 4. We had several instances of false positives on the Amphetamine test on patients who were undergoing extreme stress (a psychotic episode and a difficult childbirth) that were repeatable both here and by Biosites Tech Service lab, but could not be identified as any of the usual amphetamine-like substances. 5. The incubation time cannot be decreased without losing sensitivity, and likewise you cannot run cold specimens without losing sensitivity. Follow the manufacturer's procedure and it is an excellent (if somewhat expensive) product, however. These observations are several years old, and I can't say what kind of support the company gives these days. I wish the manufacturer of the FPIA assays I now use could be so forthcoming with cross-reactivity data. Gary Sandberg MT(ASCP) SC chemistry supervisor St.Joseph Hospital Bellingham, WA USA -----Original Message----- From: PETER HOWELL [mailto:[log in to unmask]] Sent: Wednesday, July 02, 2003 12:43 AM To: [log in to unmask] Subject: Triage Tox Drug Screen Good Morning to All Has anyone any experience of the Triage Tox Drug Screen System, either in the lab or as a POCT system ? Peter Peter Howell Wrexham Maelor Hospital Wrexham ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ ============================================================ This message is intended solely for the use of the individual and entity to whom it is addressed, and may contain information that is privileged, confidential, and exempt from disclosure under applicable state and federal laws. If you are not the addressee, or are not authorized to receive for the intended addressee, you are hereby notified that you may not use, copy, distribute, or disclose to anyone this message or the information contained herein. If you have received this message in error, immediately advise the sender by reply email and destroy this message. ============================================================ ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/