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Hi, We were just wondering what the current best practice is with regards to screening for Downs Syndrome in IVF pregnancies. Our request form currently asks if the pregnancy is IVF (tick box) so we do not generally know what type of IVF is being used. The question is: Papers have been published which suggest marker levels (HCG) are altered in IVF pregnancies (Wald et al B J OG 1999) and they published a correction factor for HCG MoMs. However, the paper is less than enthusiatic abou providing this screening service in IVF pregnancies. So do we: a) Correct and Calculate b) do no correction c) do no screening We would welcome comments/views and current practice in other centers. Craig Webster Tony Hitch Nottingham City Hospital ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/