 |
 |
Would it not be more appropriate to monitor the plasma fluoxetine levels closely? A poor metaboliser will show increased levels, and the dose could be adjusted accordingly? Would this be right? David Gerrie -----Original Message----- From: Graham Mould [mailto:[log in to unmask]] Sent: 22 October 2003 14:34 To: [log in to unmask] Subject: Re: CYP2D6 and Prozac you can measure the enzyme in a blood sample and so called genotype the person. A company called Genesolve, part of LGC is a company that tested for that enzyme (CYP2D6) as well as the other cytochrome variants. I think LGC is at Teddington and Genesolve is a spin off from the University of Dundee. I think Chandos Clincial research in Park Royal, London also measures it. You could measure it whilst the pateint is taking the drug. The analysis is (or was) expensive, and I don't think it's worth testing all patients, in fact its not worth testing any patient really. However the question of whether one should 'metabolically' categorize patients into slow or rapid (or intermediate) metabolisers is another debate. Hope this is useful. Graham Mould -----Original Message----- From: PETER HUDSON [mailto:[log in to unmask]] Sent: 22 October 2003 10:33 To: [log in to unmask] Subject: CYP2D6 and Prozac Dear all This morning, a patient on Prozac, presented her GP with a sheaf of documents which she has obtained from the internet about the CYP2D6 enzyme. This enzyme is involved in the metabolism of Fluoxetine. Apparently 10% of people have a low activity. Poor metabolism of the drug by an individual has resulted in legal action in the USA. The patient has asked to be tested. Does anyone do this? Is it possible to detect CYP2D6 phenotype when the patient is already taking the drug? The Gp also asks, if an assay is available, should he be testing all his patients on Prozac? Thanks Peter Hudson Peter Hudson Principal Biochemist Wrexham Maelor Hospital Wales, UK. LL13 7TD [log in to unmask] ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ -- -- Disclaimer **************************************************************************************** This e-mail may contain confidential and / or privileged information. Unless otherwise specified, the opinions expressed herein do not necessarily represent those of Guy's and St Thomas Hospital NHS Trust or any of its subsidiaries. If you are not the intended recipient (or have received this e-mail in error) please notify the sender and destroy this e-mail immediately. Any unauthorised copying, disclosure or distribution of the material in this e-mail is strictly prohibited **************************************************************************************** ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/