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I have picked up some of these issues with our haematologists and have attached our local DVT protocol.
 
The probability of a D- dimer being negative in moderate and high risk patients with conformed DVT (as defined in the attached algorithm) is 2-3% and 20% respectively. My colleagues do not currently reccommend a d-dimer assay being performed in these patients presenting to the ED. It is only used in low probability patients.
 
D-dimer is also not currently reccommended to rule out DVT  in in-patients. iI there is clinical suspicion of DVT in this latter group they proceed directly to U/S.
 
I would be interested in your coments.
 
John Black
Oxford
-----Original Message-----
From: Biggin Chris (RTF) NHCT [mailto:[log in to unmask]]
Sent: 07 October 2002 16:38
To: [log in to unmask]
Subject: Re: D-dimers and DVT

I had thought that a D-dimer should not be requested on a patient with a clinical scoring of 3 or more as this was a high risk group for DVT. The patient should instead have a doppler etc.  A normal D-dimer test in a high risk group would not be a 100% reassuring.
Absolutely agree with you - I've just had a barney with a medical SHO last night regarding this exact point. Many people question the content and quality of current A&E training in this country, but critical appraisal and a cursory understanding of stats is probably one of the FFAEM's successes. I think this often leaves us in a situation now of having a better understanding than many other practitioners of the value of a test, and the fact that tests alter probabilities rather than giving"Yes/No" answers. Once other specialties catch up, I wonder whether we'll face quite the same problems.
 
Chris Biggin
North Tyneside
-----Original Message-----
From: Ray McGlone [mailto:[log in to unmask]]
Sent: 05 October 2002 21:35
To: [log in to unmask]
Subject: D-dimers and DVT

I had thought that a D-dimer should not be requested on a patient with a clinical scoring of 3 or more as this was a high risk group for DVT. The patient should instead have a doppler etc.  A normal D-dimer test in a high risk group would not be a 100% reassuring.
 
However a trend has developed locally for all patients to need a D-dimer before any further investigation. So a Doppler may be refused even if the patient obviously has a DVT. e.g. drug addict injecting into groin with leg twice normal size.
 
What is happening in other hospitals?
 
 
Ray McGlone
 
A&E Consultant
Royal Lancaster Infirmary / Westmorland General Hospital
 
http://www.mbha.nhs.uk/morecambe_bay_hospitals_trust.htm