 |
 |
Dear SPM users, we developed a SPM add-on for the fully automated modeling of dynamic PET studies using the Ichise non-invasive plot. The toolbox, inclusive example dataset, is available via e-mail (~3.Mb). Best regards, Florian Florian Wilke University Hospital Hamburg Department of Nuclear Medicine Martinistr. 52 20246 Hamburg Germany e-mail: [log in to unmask] %********************** Modeling Tool ******************************* % % developed by Florian Wilke and Ralph Buchert % Department of Nuclear Medicin % University Hospital Hamburg-Eppendorf % Copyright (C) 2002 % % Contact: [log in to unmask] % [log in to unmask] % % Features: Batch Mode of % SPM realignment, % SPM stereotactic normalization, % and quantification of dynamic PET or SPECT studies % VOI-statistic % % This program is free software under the terms of the GNU General Public License. % It is developed and tested under Windows NT and Matlab 5.3 % % and comes WITHOUT ANY WARRANTY ! % % See the GNU Genaral Puplic License for more details. % % With respect to the Members of the Welcome Department of Cognitve Neurology % this tool use many SPM functions (s. www.fil.ion.ucl.uk/spm). % % We hope it will be usful. % % % Basic concepts of Preprocessing and Quantification: %----------------------------------------------------------------------- % % REALIGNMENT: The early time frames of dynamic PET and SPECT data do not provide % sufficient anatomical information for the convergence of the SPM realignment % tool. Therefore, assuming that there is no relevant movement during the early frames, % the transformation parameters of the first "good" frame are applied to the % early frames, too. % % STEREOTACTIC NORMALIZATION: Stereotactic normalization allows the use of % standardized volumes of interest for the generation of time activity curves or the % VOI-based evaluation of parametric images. % % QUANTIFICATION: Modeling of dynamic PET studies using the Ichise non-invasiv plot. % (Ichise, M. et al., Noninvasive quantifcation of dopamine D2 receptors with iodine-123- % IBF SPECT. J Nucl Med, 1996. 37(3): p. 513-520 ) % % STATISTICAL ANALYSIS: For voxelwise statistical analysis use SPM, for VOI-wise % statistical analysis mt_voistat may be used. % % EXAMPLE: There is a worked example available.