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Dear SPM'ers, Having completed a comprehensive ROI analysis on our Neuroreceptor SPECT imaging data, we have identified several regions of statistical significance. We then repeat the analysis using SPM. My question is, can I use the uncorrected values calculated from SPM as I have prior information from our ROI analysis on areas showing statistical significance. Of course making the appropriate multiple comparisons correction if we have several regions. Is this approach valid? I was also led to believe that you can only make apriori hypotheses from other published literature. If anybody can clarify this for me, I'd be grateful. Cheers Sean Colloby Research Associate Imaging Research Group Institute for Ageing and Health Wolfson Research Centre Newcastle General Hospital Newcastle-upon-Tyne NE4 6BE UK Tel: +44 (0) 191 256 3372 Fax: +44 (0) 191 219 5051 email: [log in to unmask]