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Hi Ed, I hope that the fact you are now asking about MNI - tlrc transforms means that you got your flirt registrations to work ok in the end. For MNI-tlrc I assume you are talking about the transformation that Matthew Brett has developed. It would be possible to code this up as a warp field and then apply it using applywarp. You would just have to go through each voxel, use the coordinate transformation and save the result in a warp field (3 x 3D volumes, saved as a 4D volume, one for each coordinate component). The difficulty would be getting the origin and axes correct, especially for viewing in other software like AFNI. I'm afraid I don't quite know enough about AFNI to make this work though. If anyone does know how to set the AFNI origin and axes for a general analyze image then we should be able to get this approach to work fine. Cheers, Mark On Thursday, November 14, 2002, at 10:26 AM, Edward Vessel wrote: Edward Vessel <<[log in to unmask]> Hi there - After using flirt to normalize subjects to the avg152T1 brain, I'd like to further transform these datasets into tlrc coordinates (and, preferably, a tlrc box as well) so that the labels and coordinates given in AFNI are more correct. I am a aware of a few programs which take single MNI coordinate values and output the tlrc values, but I was wondering if there is a tool to convert whole 3D volumes(in analyze or AFNI format) from MNI space to tlrc. thanks, Ed -- Ed Vessel U. of Southern California [log in to unmask] Dept. of Neuroscience HNB, 3641 Watt Way 1A1A,1A1A,FFFFhttp://geon.usc.edu/~vessel Los Angeles, CA 90089-2520 (213) 740-6102