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What generation of TNT reagent was used in these papers? The generation 2 TNT did respond markedly to skeletal forms of TNT and the current generation 3 is more specific for cardiac TNT. In our experience with generation 3 TNT is the only false positive TNT results are from renal patients. cheers "We tortured the data until it confessed." Trevor Walmsley, Canterbury Health Labs, Christchurch, New Zealand. Phone: (0064 3) 364 0326 Fax:Phone: (0064 3) 364 0320 eMail: [log in to unmask] Internet: http://www.cdhb.govt.nz/chlabs/staff/trevorw.htm >>> "Firth, Gary" <[log in to unmask]> 21/3/02 5:04 am >>> Whilst putting together a presentation on troponin T for our medical staff I have come across several papers that indicate that Troponin T (but rarely I) is raised in some cases of polymyositis and dermatomyositis. The suggestion made in at least one paper (Clin Chim Acta 2001; 306:27) is that this may be due to release of cTnT from skeletal muscle. Does anyone have any evidence to support or refute this suggestion or is this indeed the exception that proves the rule? Gary Firth Princess Royal Hospital Sussex ********************************************************************** This email and any files transmitted with it are confidential and intended solely for the use of the individual or entity to whom they are addressed. If you have received this email in error please notify the system manager. This footnote also confirms that this email message has been swept by MIMEsweeper for the presence of computer viruses. www.mimesweeper.com ********************************************************************** ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/