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Dear Mike, Can I raise a different issue from that in my other email, namely the Acute Phase Reaction. Many of our ICU patients have a severe APR with for example CRP over 250, and BCP albumin down in the 8 to 15 region. I've not come across any valid method to assess serum Mg in this context, such as there is for calcium. But I suspect that results of say say 0.6 mmol/l, maybe lower, are not necessarily "abnormal". Does anyone know of hard data to interpret serum Mg in these patients? Best wishes, Les > From: [log in to unmask] > Reply-To: [log in to unmask] > Date: Tue, 23 Jul 2002 11:05:11 +0100 > To: [log in to unmask] > Subject: Magnesium infusions > > Like many of you I suspect we have observed an exponential rise in > requests or plasma magnesium from our ICU in the last few years. > This started with patients with meningococcal meningitis but now > almost all patients have magnesium results several times a day. I > confess to not having done an extensive literature search but I am > pretty sure that the evidence base for the clinical usefulness of these > measurements is pretty thin. It must be incredibly difficult to sort out > the effects of a low plasma magnesium from all the other problems in > patients on ICU. > > However, now a new phenomenon has arisen which is the treatment of > patients plasma magnesium concentrations in the low normal range > with magnesium infusions leading in at least one case to a > concentration well above the upper reference limit. On talking to one > of my adult colleagues I find we are not alone and this is happening > elsewhere. Can anyone shed any light on this? Are there real dangers > in this apparently cavalier approach to treating biochemistry and not > the patient? > > Mike Addison > . > Dr G.Michael Addison > Royal Manchester Children's Hospital > Pendlebury > Manchester M27 4HA > United Kingdom > > Tel 0161-727-2250(AM)or 0161-220-5342(PM) > FAX 0161-727-2249 > Email [log in to unmask] > > ------ACB discussion List Information-------- > This is an open discussion list for the academic and clinical > community working in clinical biochemistry. > Please note, archived messages are public and can be viewed > via the internet. Views expressed are those of the individual and > they are responsible for all message content. > > ACB Web Site > http://www.acb.org.uk > List Archives > http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html > List Instructions (How to leave etc.) > http://www.jiscmail.ac.uk/ ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/