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Most of the papers I have seen use the Sodergard formula. The differences are irrelevant as free testosteerone calculation is not an eact science at the moment. The important thing is to decide on your preference and then calculate your own reference range from normal subjects. I am not a great advocate of its use in men as I don't think it adds anything to testosterone, LH and FSH unless you know the patient is on a liver inducer e.g. phenytoin. Your reference range in women will depend how you determine your reference range. I have just collected samples from normal menstruating non-obese young medical students and got lower testosterone levels than if I collect routine samples going through the lab for women with a 21 day progesterone >30 nmol/L. Presumably because some of the latter will be menstruating PCO women. Mike Wheeler ----- Original Message ----- From: "James Davidson" <[log in to unmask]> To: <[log in to unmask]> Sent: Wednesday, April 03, 2002 5:15 AM Subject: SHBG association constant > Does anyone have a view on the most appropriate value of the SHBG- > testosterone association constant to use for calculation of free > testosterone in clinical samples?. Sodergard et al (J. Steroid Biochem 16 > (1982)801) use a value of 0.6 L/nmol but also quote several other values > from earlier literature. Vermeulen et al (J Clin Endo Metab 84(1999)3666) > suggest using 1.0 L/nmol. These values differ by 40% and therefore give > significantly different calculated values for free testosterone. > > ------ACB discussion List Information-------- > This is an open discussion list for the academic and clinical > community working in clinical biochemistry. > Please note, archived messages are public and can be viewed > via the internet. Views expressed are those of the individual and > they are responsible for all message content. > > ACB Web Site > http://www.acb.org.uk > List Archives > http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html > List Instructions (How to leave etc.) > http://www.jiscmail.ac.uk/ ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/