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Using the blood gas analysers is attractive. How do you handle the
requests for bilirubin analysis that come from sources other than the
neonatal unit? Have a blood gas analyser in the laboratory, or some
other approach?

Dr Jonathan Kay


On Friday, November 15, 2002, at 05:43 PM, Fry, John wrote:

> All samples on SCBU that are analysed for blood gases automatically
> have a
> bilirubin result. Yes, the problem was I believe in one of the
> mathematical
> formulae used to 'produce' a bilirubin result.
>
> Prior to purchasing this machine, we did look at a number of
> 'bilirubinometers'  but, since the blood gas machine on SCBU was
> almost due
> for replacement, combining the two instruments was the most cost and
> clinically effective method of progress.
>
> John Fry
>> ----------
>> From:         PETER HOWELL[SMTP:[log in to unmask]]
>> Reply To:     ACB Point of Care Testing List
>> Sent:         15 November 2002 15:34
>> To:   [log in to unmask]
>> Subject:      Re: Bilirubinometers
>>
>> Hi John
>>
>> The potential 'controversy' was over the performance of bilirubin on
>> the
>> analyser, not the use of the analyser for one-off bilirubin
>> measurements.
>> This would not seem to be apparent from your experience, but I
>> remember
>> some doubts from somewhere. I'll search my 'memory banks' !
>> Would your SCBU staff use the blood gas analyser to do JUST a
>> bilirubin,
>> or would they measure blood gases/electrolytes at the same time, even
>> if
>> the baby didnt require them ?
>> Do you see what I mean ??
>>
>> Peter
>>
>>
>>> -----Original Message-----
>>> From: Fry, John [SMTP:[log in to unmask]]
>>> Sent: 15 November 2002 15:30
>>> To:   [log in to unmask]
>>> Subject:      Re: Bilirubinometers
>>>
>>> As far as the analytical side goes, our NEQAS returns are good, as is
>> the
>>> correlation with the main analysers in the department. Neither the
>> technical
>>> staff or myself are aware of the controversy you have mentioned
>> regarding
>>> one off bilirubin in sick neonates.
>>>
>>> John Fry
>>> Clinical Biochemist
>>>
>>>> ----------
>>>> From:         PETER HOWELL[SMTP:[log in to unmask]]
>>>> Reply To:     ACB Point of Care Testing List
>>>> Sent:         15 November 2002 13:18
>>>> To:   [log in to unmask]
>>>> Subject:      Re: Bilirubinometers
>>>>
>>>> Isn't there some 'controversy' about how good these analysers are at
>>>> measuring bilrubin ??
>>>>
>>>> And its OK if you are also measuring blood gases/ electrolytes at
>>>> the
>> same
>>>> time, but not really for just a one-off bilirubin on a 'well' baby.
>>>>
>>>> Peter
>>>>
>>>> Peter Howell
>>>> Head Biomedical Scientist
>>>> Medical Biochemistry Department
>>>> Wrexham Maelor Hospital
>>>> Wrexham
>>>>
>>>>
>>>>> -----Original Message-----
>>>>> From: Fry, John [SMTP:[log in to unmask]]
>>>>> Sent: 15 November 2002 13:16
>>>>> To:   [log in to unmask]
>>>>> Subject:      Re: Bilirubinometers
>>>>>
>>>>> One possible answer is to purchase one of the Radiometer 7 series
>> blood
>>>> gas
>>>>> analysers which incorporates an analytical uniit for bilirubin
>> assays on
>>>> the
>>>>> whole blood sample. Centrifugation of capillary samples is then a
>> part
>>>> of
>>>>> history.
>>>>>
>>>>> John Fry
>>>>> Worthing Hospital
>>>>>
>>>>>> ----------
>>>>>> From:         Evans, Francis -
>>>> RCHT[SMTP:[log in to unmask]]
>>>>>> Reply To:     ACB Point of Care Testing List
>>>>>> Sent:         15 November 2002 11:58
>>>>>> To:   [log in to unmask]
>>>>>> Subject:      Re: Bilirubinometers
>>>>>>
>>>>>> I have been concerned for 'ages' about the infection risk involved
>> in
>>>>>> spinning capillaries for bilirubins in our SCBU laboratory.  We do
>>>> have a
>>>>>> separate lab to contain the gas analyser and bilirubinometer but
>> the
>>>>>> aerosol
>>>>>> problem when capillaries leak and eject their contents is of
>>>> considerable
>>>>>> concern.  I have not been able to get any manufacturer to supply a
>>>>>> properly
>>>>>> sealed rotor to contain spills.
>>>>>>
>>>>>> I would also be interested to hear other views on suitable
>>>> alternatives.
>>>>>>
>>>>>> Francis Evans
>>>>>> Chief BMS
>>>>>> Clinical Chemistry
>>>>>> Royal Cornwall Hospitals Trust
>>>>>> Truro  TR1  3LJ
>>>>>>
>>>>>>
>>>>>>
>>>>>> -----Original Message-----
>>>>>> From: Paul Eldridge [mailto:[log in to unmask]]
>>>>>> Sent: Friday, November 15, 2002 10:05
>>>>>> To: [log in to unmask]
>>>>>> Subject: Bilrubinometers
>>>>>>
>>>>>>
>>>>>> I have sent this to both the POCT list and ACB clin chem list.
>>>> Apologies
>>>>>> to those who get it twice.
>>>>>> Two problems/questions:
>>>>>> 1. Infection in ward areas by centrifuges.
>>>>>> It has been reported by a new paediatric doctor here that
>>>>>> bilirubinometers have been removed from wards in 2 SW London
>> hospitals
>>>>>> because of infection risks from the centrifuges used to spin down
>> the
>>>>>> capillary tubes.
>>>>>> Have others experienced this problem?
>>>>>> Is there a centrifuge available that can be sealed?>
>>>>>> Is there any good experience with non invasive bilirubin
>> measurements?
>>>>>>
>>>>>> 2. We recently replaced our TIME ward bilirubinometer with the
>> Digital
>>>>>> Analogue Systems NEO BIL instrument distributed by Schuco in the
>> UK.
>>>> It
>>>>>> very simple to operate by the ward staff but cannot be calibrated
>> by
>>>> the
>>>>>> lab. It has a non linear response noted by positive bias below 300
>> and
>>>>>> negative above this level. This has been shown by studies on EQAS
>>>>>> samples and our dilution studies.
>>>>>> Do others have the problem and how do you overcome it ?
>>>>>>
>>>>>> Many thanks in advance.
>>>>>>
>>>>>>
>>>>>> Dr Paul H Eldridge
>>>>>> Clinical Biochemist
>>>>>> University Hospital Lewisham
>>>>>> London SE13 6LH
>>>>>> UK
>>>>>> Phone: (44) 020 8333 3255
>>>>>> Fax:      (44) 020 8690 8891
>>>>>>
>>>>>>
>>>>>> [log in to unmask]
>>>>>>
>>>>>>
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