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This subject has probably been aired on the mailbase in the past but I would like to make an enquiry about how people correct calcium for serum albumin concentration (I do not want a lecture on the benefits of ionized calcium as I am fully aware of the arguments!). It has been my personal practice based on early literature not to correct calcium downward in the presence of high albumin concentrations. This was based on the fact that albumin concentrations can be acutely changed upwards during venous stasis and that this could temporarily disturb the equilibrium between albumin and calcium. My understanding could be wrong and discussions in my own lab have left us not knowing whether it is safe and valid to correct calcium down. Your thoughts and evidence will be much appreciated Mike Addison Dr G.Michael Addison Consultant Chemical Pathologist Department of Clinical Biochemistry Royal Manchester Children's Hospital Pendlebury Manchester M27 4HA United Kingdom Tel 0161-727-2250(AM)or 0161-220-5342(PM) FAX 0161-727-2249 Email [log in to unmask] ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/