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Important as this issue is, I think that the variability of the bias inherent in the newer, direct HDL assays, relative to their predecessors is of infinitely greater concern. Dermot ****************************************** Dr RDG Neely Department of Clinical Biochemistry Newcastle upon Tyne Hospitals NHS Trust Royal Victoria Infirmary Newcastle upon Tyne NE1 4LP Tel. 0191 2824554 Fax. 0191 2820381 [mailto:[log in to unmask]] ****************************************** The opinions expressed in this message are those of the author and do not reflect those of NUTH NHS Trust unless stated. The contents of this E-mail are intended for the addressee only. -----Original Message----- From: William Marshall [mailto:[log in to unmask]] Sent: 04 July 2002 09:53 To: [log in to unmask] Subject: Re: HDL assays The most rational approach might be to report to a level of significance that is reflected in the confidence limits for the measurement. Doug Hirst may remember that we tried this once at King's and no one understood it. The practical problem with reporting data using a level of significance that reflects the analytical precision is that this can mislead users who forget that biological variation is likely to be greater than analytical variation and may ascribe inappropriate clinical significance to the difference between a result and a reference value or a previous result in the same patient. WM At 15:55 03/07/2002 +0100, Graham Mould wrote: >Following from the discussion about HDL measurements, I notice that most >of the HDL results reported by laboratories are to one place of decimal. >We are conducting a clinical trial (for an Americian company) where I have >been asked to ask our laboratory to report to two places of decimal. The >Americians argue that an increase from 35 to 40mg/dL is more significant >than going from say 1.0 to 1.1 mmol/L. The laboratory, quite correctly >have suggested, that the assay may not be sensitive enough to go to two >places accurately, although the triglycerides are reported to two places >of decimal. What do other labs do? >Graham Mould, >Guildford Clinical Pharmacology Unit, >Royal Surrey County Hospital, >Egerton Road, >Guildford, Surrey, UK >GU2 7XX. >Tel:44 (0)1483 406886. >Fax: 44 (0)1483 455375. > >------ACB discussion List Information-------- >This is an open discussion list for the academic and clinical >community working in clinical biochemistry. >Please note, archived messages are public and can be viewed >via the internet. Views expressed are those of the individual and >they are responsible for all message content. > >ACB Web Site >http://www.acb.org.uk >List Archives >http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html >List Instructions (How to leave etc.) >http://www.jiscmail.ac.uk/ From: Dr William J Marshall Reader and Hon Consultant in Clinical Biochemistry GKT School of Medicine London SE5 9PJ UK telephone: 020 7346 3275 facsimile: 020 7737 7434 email: [log in to unmask] ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/ ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/