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Paul, A physician practising in a Rheumatology/Neurology setting told me that she finds aldolase helpful in deciding whether to refer patients with mild to moderate elevated total CK and unexplained myositis for further testing , i.e. myographic workup. She said that if the aldolase is elevated in these patients, they will be sent for more costly elaborate work up, but if it is normal, they were just closely monitored. I too feel that routine measurements of aldolase for skeletal muscle disorders are not very useful. Any further comments on this? Thanks Godfrey Moses Godfrey Moses, BSc., MSc., PhD, FCACB Clinical Biochemist Medical Support, MDS Inc. [log in to unmask] 416-675-6777 ext 2363 -----Original Message----- From: Paul Collinson [mailto:[log in to unmask]] Sent: Wednesday, December 05, 2001 5:03 PM To: [log in to unmask] Subject: Re: Aldolase In message <[log in to unmask] >, Graham Jones <[log in to unmask]> writes >Dear Colleagues, > >I am writing concerning the use of aldolase as a marker of skeletal muscle >damage. My understanding is that in nearly all circumstances it has no >advantage over total CK activity. The only exceptions I can envisage is >where the CK result is unreliable for some reason (eg the presence of a >macro CK). > >One of my neurology colleagues has suggested that in neurology folklore >aldolase is sometimes helpful when CK is normal. > >Can anyone support or contradict my current understanding? > >Many thanks, > >Graham > >Graham Jones > >Staff Specialist in Chemical Pathology >St Vincent's Hospital, Sydney >Victoria St, Darlinghurst, 2010 >NSW, Australia >Ph: (02) 8382-2170 Fax (02) 8382-2489 >[log in to unmask] > > >********************************************************************** >This email and any files transmitted with it are confidential and >intended solely for the use of the individual or entity to whom they >are addressed. If you have received this email in error please notify >the system manager. > >This footnote also confirms that this email message has been >virus scanned and although no viruses were detected by the system, >St Vincent's Hospital accepts no liability for any consequential >damage resulting from email containing any computer viruses. > >********************************************************************** Aldolase went out with the ark CK is more sensitive. If there are queries CK isoforms are helpful -- Paul Collinson ------ACB discussion List Information-------- This is an open discussion list for the academic and clinical community working in clinical biochemistry. Please note, archived messages are public and can be viewed via the internet. Views expressed are those of the individual and they are responsible for all message content. ACB Web Site http://www.acb.org.uk List Archives http://www.jiscmail.ac.uk/lists/ACB-CLIN-CHEM-GEN.html List Instructions (How to leave etc.) http://www.jiscmail.ac.uk/