Dear SPM I am trying to specify a model to examine a group of 7 controls that were scanned at 3 time points (using fMRI). I am trying to determine whether the regression slopes of the individual controls are different from zero. I would also like to estimate the mean activation over the 3 time points per patient. I have the individual contrast images (21 in total) and am using the PET models box. I can calculate the group regression slope across time points (I can also do this with Basic Models in fMRI). However I cannot seem to specify a model with the subjects in a separable fashion which lets me get at the individual regression slopes and means. This is because I keep getting errors: If I try the single subject: Condtions and covariates option I get the following error after entering the data as 21 conditions: ??? Error while evaluating uicontrol Callback. >> ??? Error using ==> spm_spm_ui unestimable condition effects If I try the multi-subj: cond x subj interactiona and covariates, and enter the 7 subjects and 3 conditions, I get the following error: ??? Error using ==> spm_spm_ui unestimable condition effects ??? Error using ==> pause Error while evaluating uicontrol Callback. ??? Error while evaluating uicontrol Callback. >> ??? Error using ==> set Invalid handle. Error in ==> /local/SPM99/spm_input_ui.m On line 850 ==> set(h,'Style','Edit',... Error in ==> /local/SPM99/spm_input.m On line 65 ==> [varargout{:}] = spm_input_ui(varargin{:}); Error in ==> /local/SPM99/spm_spm_ui.m On line 1496 ==> ti2 = spm_input([str,' ',DsF{2},'?'],GUIpos2,'c',ti2',n21,Dn(2)); Error in ==> /local/SPM99/spm_spm_ui.m On line 802 ==> [P,I] = spm_spm_ui('Files&Indices',D.sF,D.n,D.b.aTime,nVar); Is there a problem with the way I am specifying the models or is it something else? Thanks Ahmed Toosy