Dear SPM, I wonder how the .mat file that is created with reorientation relates to the new origin. For example, if I have the Source image and the .mat file, how is the .mat file used to create the Destinantion. The reorientation looks good but the numbers in what I thought was the translation column in the matrix are (I think) very high, sometimes > FOV/2. Thanks in advance Jimmy -------------------------------------------- Jimmy Jensen, PhD PET centre Centre for Addiction and Mental Health Clarke Division 250 College St. Toronto, ON, M5T 1R8 Phone (416) 535-8501 ext. 6280 Fax (416) 979-4656