The next series of seminars are due to start at the end of March 2001. They are held on Tuesday afternoons at 4pm (except 19 April, which is on Thursday). All are welcome. The topics are as follows : 20 March Professor Tony McMichael, London School of Hygiene & Tropical Medicine. Climate change and health: can we estimate the risk? 27 March Dr Thomas Dormandy Whittington Hospital, London (retired). The image of an illness: tuberculosis in the bourgeois century. This seminar is based on his recent book "The White Death: A history of tuberculosis", which describes the social, artistic and human impact of this very prevalent disease, some of which is still not perhaps widely recognised. 3 April Dr Alan Malcolm, Chief Executive, Institute of Biology, London. Manna or mania - some reflections on genetically modified (GM) products 10 April Professor George Miller, MRC Epidemiology & Care Unit, St Bartholomew's & The Royal London School of Medicine Clotting factor VII and fat-rich meals Factor VII plays a key role in the initiation of coagulation and arterial thrombosis. Therefore its transient activation after fat-rich meals has been a cause for concern. The mechanism of this postprandial effect has been elusive, but studies have now provided new insight. 17 April Professor John Dickinson, Emeritus Professor. St Bartholomew's & The Royal London School of Medicine Why are strokes related to hypertension? Stroke and hypertension are strongly associated. This review considers the following questions, none of which at present have a definitive or generally agreed answer: (i) why does hypertension predispose to stroke? (ii) why is cerebral infarction closely related to cerebral haemorrhage? (iii) why does lowering blood pressure prevent strokes? and (iv) is the stroke-prone spontaneously hypertensive rat relevant to studies of stroke in man? 19 April Dr Peter MacCallum Wolfson Institute of Preventive Medicine Hormone replacement therapy and cardiovascular disease. 24 April Dr Paula Williamson University of Liverpool The treatment of epilepsy: reviewing the evidence The focus of the Cochrane Epilepsy Group is on assessing the outcomes of interventions designed to prevent and manage childhood and adulthood seizures and epilepsy. In this talk, I shall discuss the reviews of anti-epileptic drug monotherapies involving individual patient meta-analyses. Statistical issues highlighted include outcome definition, misclassification, heterogeneity and the idea of borrowing strength across analyses of related questions. 1 May Dr Basil Hetzel, Chairman, International Council for Control of Iodine Deficiency Disorders, Australia. The global elimination of brain damage due to iodine deficiency. Iodine deficiency is recognised by the WHO as the most common preventable cause of brain damage. A global program has been operating since 1990 when the World Summit for Children listed elimination of iodine deficiency disorders (IDD) as a goal for the year 2000. The International Council for Control of Iodine Deficiency Disorders (ICCIDD) has been the scientific resource recognised by the WHO. There are 130 IDD affected countries with a population of 2 billion at risk of which 109 now have programs for the elimination of IDD. Progress has been remarkable with two thirds of households in 1999 having access to iodized salt. Allan Hackshaw Lecturer in Epidemiology & Medical Statistics Wolfson Institute of Environmental & Preventive Medicine St Bartholomew's & The London School of Medicine & Dentistry Queen Mary, University of London Charterhouse Square London EC1M 6BQ Telephone: (+44) (020) 7982 6283 Fax: (+44) (020) 7982 6270 email: [log in to unmask]