(I sent this yesterday but it didn' show up on the list...) Dear Kalina I was trying your routine glm_specmask and I saw that the mask created from the gray matter covers really the entire brain. I reduced the smoothing to 3mm (original img was .9375 x .9375 x 5) and the results seemed better. What do you think about it? (I sent the img in attachment). Also I was wondering if there is any special reason why the routines for ROI analysis may not apply to unnormalized data (which may be more suitable for the ROI approach...). Lastly, does anybody know a way to get the voxels timecourses of an anatomically specified ROI mask (say, created with MRIcro)? I think the question has been asked before but I cannot find it on the list. thanks for your time Giuseppe ---------------------------------------------------------------------------- ----------- Giuseppe Pagnoni, Emory University Dept. of Psychiatry and Behavioral Sciences 1639 Pierce Drive, Suite 4000 WMB Bldg., Atlanta, GA 30322 phone: 404 -727-8259 404-727-7002 fax: 404-727-3233 e-mail: [log in to unmask]