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> Is it true that the pre-processing procedures such as alignment, > coregistration, smooth, slice timing, and normalization do not have > to follow some kind of order to apply to fMRI data before statistical > processing? > Logically, there may be some kind of order, but mathematically, these > procedures can be applied at any sequence order, and the results would > not be "too much" different. I thought I'd better just add a little more to Alle Meije's answer... I would strongly suggest that you follow the prescribed order of pre-processing as the steps are not commutative. e.g., warped images do not match together well with a rigid registration, smoothing before warping produces nonstationary smoothness etc...etc.. Best regards, -John -- Dr John Ashburner. Wellcome Department of Cognitive Neurology. 12 Queen Square, London WC1N 3BG, UK. tel: +44 (0)20 78337491 or +44 (0)20 78373611 x4381 fax: +44 (0)20 78131420 http://www.fil.ion.ucl.ac.uk/~john mail: [log in to unmask]